Despair has been called the unforgivable sin--not presumably because God refuses to forgive it but because it despairs of the possibility of being forgiven.
He who despairs of the human condition is a coward, but he who has hope for it is a fool. - Albert Camus
The human heart is a dark, unyielding mystery. It is a perforated jug with a mouth forever open; though all rivers of the earth pour in, it will remain empty and thirsting. The greatest of hopes had not filled it. Would it be filled now by the greatest of despairs? (Report to Greco) - N. Kazantzakis
He who despairs over an event is a coward, but he who holds hope for the human condition is a fool. - Albert Camus